文章摘要
郑新,周丹,李春艺,陈恒,曾伟兰,王缉义.产妇口服拉贝洛尔对母乳喂养新生儿安全性的探讨[J].中国医药导刊,2017,19(12):1369-1372.
产妇口服拉贝洛尔对母乳喂养新生儿安全性的探讨
A Discussion of Neonatal Safety of Breastfeeding When Parturient Women Taking Labetalol
投稿时间:2017-09-12  修订日期:2017-11-10
DOI:
中文关键词: 拉贝洛尔  母乳喂养  新生儿  安全性  妊娠高血压
英文关键词: Labetalol  Breastfeeding  New born infants  Safety  Gestational hypertension
基金项目:2016年玉林市科学研究与技术开发计划项目(项目编号:20161605;项目名称:口服拉贝洛尔在母乳中含量分布及其对新生儿安全性的研究)
作者单位E-mail
郑新 玉林市妇幼保健院 ylsfyzhx@163.com 
周丹 玉林市妇幼保健院  
李春艺 玉林市妇幼保健院  
陈恒 玉林市妇幼保健院  
曾伟兰 玉林市妇幼保健院  
王缉义 玉林市妇幼保健院  
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中文摘要:
      目的:探讨产妇口服拉贝洛尔对母乳喂养新生儿的安全性,为促进合理用药及母乳喂养提供参考。方法:选取2016年10月至2017年7月分娩的120例新生儿为研究对象,以产后继续口服拉贝洛尔的妊娠期高血压产妇新生儿为观察组,按1∶1以同日未给予任何治疗药物的健康产妇新生儿为对照组,各60例,对比两组新生儿的临床情况。结果:两组新生儿具有可比性。观察组新生儿开奶前、哺乳后24h及48h血压、心率,哺乳前后血常规、肝功能、肾功能异常情况,黄疸发生率、程度和消退时间分别与对照组比较,差异均没有统计学意义(P均>0.05)。观察组60例新生儿均未出现多汗、反应差、胃肠道不适、皮疹、呼吸加快等临床表现,停药7d后及分娩后28d的随访情况也无明显异常。结论:妊娠期高血压产妇口服常规剂量拉贝洛尔期间对母乳喂养的新生儿不产生不良影响,不必限定暂停哺乳。早产儿则需要更进一步针对性研究。
英文摘要:
      Objective: To discuss neonatal safety of breast feeding when parturient women taking labetalol, give reference to rational use of drug and breast feeding. Methods:120 newborn infants who were born during October 2016 to July 2017 were chosen as examples and separated into two groups in proportion of 1∶1 and each group has 60 examples. The observation group was for infants and parturient women with gestational hypertension who continued taking labetalol. The control group was for healthy infants and parturient women who never took any medical treatments during the day. Infants′ clinical conditions in each group were observed. Results: The newborn infants in these two groups were comparable. In the two groups, infants′ blood pressure and heart rate were examined before beast feeding, 24h and 48h after breast feeding. Before and after breast feeding, the abnormal condition of blood routine, liver and renal function and the rate of jaundice appearance and regression were also examined. Compared with the control group, the differences of the results were not statistically significant (P>0.05). All the newborn infants in the observation group didn′t have adverse reaction such as hyperidrosis, poor response, gastrointestinal discomfort, rash, quicken respiration etc. 7d after drug withdrawal and 28d after delivery, there was not abnormal. Conclusion:There are no bad influences for newborn infants if parturient women with gestational hypertension takes labetalol when breast feeding, it is no need to restrict lactaion. Further pertinence studies on premature infants are needed.
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