文章摘要
魏叶叶,马建萍.太芪培元颗粒治疗HIV感染者临床疗效观察[J].中国医药导刊,2017,19(12):1378-1381.
太芪培元颗粒治疗HIV感染者临床疗效观察
Observation of Clinical Curative Effect of Taiqipeiyuan Granules to HIV-infected Patients
投稿时间:2017-11-03  修订日期:2017-11-03
DOI:
中文关键词: 太芪培元颗粒  人类免疫缺陷病毒  CD4+T淋巴细胞  中医症状积分
英文关键词: Taiqipeiyuan granules  HIV  CD4+T lymphocyte  TCM symptom integrals
基金项目:国家“艾滋病和病毒性肝炎等重大传染病防治”科技重大专项(项目编号:2014ZX10005003;项目名称:中西医结合治疗艾滋病应用技术研究);中医药防治重大疑难疾病临床服务能力建设项目(项目编号:201405;项目名称:太芪培元颗粒对艾滋病患者差异蛋白的研究)
作者单位E-mail
魏叶叶 新疆医科大学 453406332@qq.com 
马建萍 新疆医科大学附属中医医院  
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中文摘要:
      目的:观察太芪培元颗粒治疗气阴两虚肺肾不足的人类免疫缺陷病毒(HIV)感染者的临床疗效。方法:采取前瞻性队列研究的方法,纳入HIV感染者81例,给予太芪培元颗粒口服180d,按照CD4+T淋巴细胞计数上升>50个和上升<5个分为治疗有效组和治疗无效组,并按照性别、民族匹配选取10个样本进行病例观察。观察指标包括CD4+T淋巴细胞、CD8+T淋巴细胞、中医症状体征积分、HIV-RNA病毒载量的差异。结果:治疗有效组CD4+T淋巴细胞显著升高(P<0.05),中医症状体征总积分显著降低(P<0.05),治疗无效组CD4+T淋巴细胞显著降低(P<0.05)。且总样本前后比较,中医症状体征总积分降低,差异有统计学意义(P<0.05);对CD4+T淋巴细胞和中医症状总积分进行Pearson相关分析得出,治疗有效组、治疗无效组以及总样本中这种相关性均无统计学意义。结论:太芪培元颗粒可有效改善气阴两虚肺肾不足型HIV感染者中医症状总积分,且这种改善与CD4+T淋巴细胞计数的升高不具有相关性。
英文摘要:
      Objective:To observe the clinical curative effect of the HIV-infected patients who were deficiency of both qi-yin and lung-kidney by taking taiqipeiyuan granules.Methods:A prospective cohort study were conducted in 81 cases of HIV-infected patients, and oral administration of taiqipeiyuan granules were given for 180d. CD4+T lymphocyte count increased>50 and ascending<5 were grouped condition for the effective treatment group and ineffective treatment group,and 10 samples were selected according to gender and ethnic match for case observation. Observations included CD4+T lymphocytes,CD8+T lymphocytes,TCM symptom integrals,HIV-RNA virus load.Results:In the effective treatment group the increase of CD4+T lymphocytes and the decrease of TCM syndrome integrals were significant (P<0.05),and the CD4+T lymphocytes in the ineffective treatment group were significantly decreased (P<0.05).Compared with the total sample before and after treatment, the decrease of TCM symptom integration was significant (P<0.05).According to Pearson correlation analysis of CD4+T lymphocyte and TCM symptom integrals, this correlation was not statistically significant in the effective treatment group, the ineffective treatment group and the total sample.Conclusion:Taiqipeiyuan granules can effectively improve the integration of TCM symptoms in patients who was deficiency of both qi-yin and lung-kidney,and this improvement has no correlation with the increase of CD4+T lymphocyte count.
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