文章摘要
艾合买提.阿不都热依木,舒占钧,马建萍,马秀兰,张颖,曾琳,李静茹,魏叶叶.太芪培元颗粒对气阴两虚肺肾不足型HIV感染者TLR-4影响的研究[J].中国医药导刊,2017,19(12):1373-1377.
太芪培元颗粒对气阴两虚肺肾不足型HIV感染者TLR-4影响的研究
Effect of Taiqipeiyuan Granules on TLR-4 Receptor of HIV-infected Patients Who were Deficency of both Qi-yin and Lung-kidney
投稿时间:2017-11-03  修订日期:2017-11-03
DOI:
中文关键词: 太芪培元颗粒  艾滋病感染者  CD4+T淋巴细胞  HIV-RNA病毒载量  TLR-4受体
英文关键词: Taiqipeiyuan granules  HIV-infected patients  CD4+ T lymphocytes  HIV-RNA viral load  TCM symptom score
基金项目:国家中医临床研究基地建设科研专项课题(项目编号:JDZX2012163;项目名称:平艾合剂1号方治疗艾滋病气阴两虚型研究);国家中医药管理局中医药防治重大疑难疾病临床服务能力建设项目(项目编号:201409;项目名称:新疆维吾尔族HIV-1的基因变异及宿主遗传背景与耐药的相关性研究)
作者单位E-mail
艾合买提.阿不都热依木 新疆医科大学附属中医医院 1311974998@qq.com 
舒占钧 新疆医科大学附属中医医院 806221068@qq.com 
马建萍 新疆医科大学附属中医医院  
马秀兰 新疆医科大学附属中医医院  
张颖 新疆医科大学附属中医医院  
曾琳 新疆医科大学附属中医医院  
李静茹 新疆医科大学附属中医医院  
魏叶叶 新疆医科大学  
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中文摘要:
      目的:观察太芪培元颗粒对气阴两虚肺肾不足型CD4+T淋巴细胞>350个·uL-1的HIV感染者的临床疗效。方法:采用队列研究,将108例HIV感染者根据是否服用太芪培元颗粒分为暴露组及非暴露组。观察6个月,对比两组患者的CD4+T淋巴细胞、HIV-RNA病毒载量、中医症状体征积分、Toll样受体-4(toll like receptor-4,TLR-4)、白介素-10(IL-10)等指标的差异。结果:经过6个月的治疗,暴露组比非暴露组的中医症状体征积分、TLR-4受体指标变化差异有统计学意义(P<0.05)。CD4+T淋巴细胞、HIV-RNA病毒载量、IL-10等指标差异无统计学意义(P>0.05)。结论:运用太芪培元颗粒治疗气阴两虚肺肾不足型CD4+T淋巴细胞>350个· uL-1HIV的感染者,可以改善患者临床症状,稳定患者CD4+T淋巴细胞计数,抑制TLR-4受体。太芪培元颗粒可能是通过机体免疫调节的过程发挥作用。
英文摘要:
      Objective:To observe the curative effect of taiqipeiyuan granules to HIV-infected patients with CD4+ T lymphocytes>350·μL-1, who were deficiency of both qi-yin and lung-kidney.Methods:One hundred and eight HIV-infected patients in this cohort study were divided into two groups as exposure group and non-exposed group according to whether taking taiqipeiyuan granules.The exposure group was taking taiqipeiyuan granules, the non-exposed group without taking taiqipeiyuan granules. After 6 months, to observe the difference between two groups of patients with CD4+ T lymphocytes,HIV-RNA viral load,TCM symptom score,TLR-4 receptor,IL-10 and other indicators.Results:After 6 months of treatment, the difference between the two groups in TCM symptom score and TLR-4 receptor were statistically significant(P<0.05).The difference between the two groups in CD4+ T cells,HIV-RNA viral load,IL-10 and so on were not statistically significant. Conclusion:Taiqipeiyuan granules can improve the clinical symptoms of HIV-infected patients with CD4+T lymphocytes>350·uL-1, stabilize CD4+ T lymphocyte count and inhibit TLR-4 receptor.Taiqipeiyuan granules may play a role in regulating the immune process.
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