文章摘要
霍云丽,常永峰,杨敬芳,贾慧宇.PTPN22基因多态性与张家口地区汉族人群桥本甲状腺炎的相关性研究[J].中国医药导刊,2017,19(12):1306-1309.
PTPN22基因多态性与张家口地区汉族人群桥本甲状腺炎的相关性研究
Association between PTPN22 Gene Polymorphism and Hashimoto′s Thyroiditis in Zhangjiakou Han Population
投稿时间:2017-12-27  修订日期:2017-12-27
DOI:
中文关键词: 桥本甲状腺炎  蛋白酪氨酸磷酸酶非受体型22  基因多态性
英文关键词: Hashimoto′s thyroiditis  Protein tyrosine phosphatase nonreceptor-22  Gene polymorphism
基金项目:河北省张家口市科技攻关计划项目(项目编号:1321036D;项目名称:细胞毒性T淋巴细胞相关抗原-4、人转化生长因子β1基因多态性与张家口地区汉族人桥本甲状腺炎的相关性)
作者单位E-mail
霍云丽 河北北方学院附属第二医院 检验科 zhangbing95959595@163.com 
常永峰 河北北方学院附属第二医院 检验科  
杨敬芳 河北北方学院附属第二医院 检验科  
贾慧宇 河北北方学院附属第二医院 检验科  
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中文摘要:
      目的:分析蛋白酪氨酸磷酸酶非受体型22(PTPN22)基因-1123G>C位点(rs2488457)多态性与桥本甲状腺炎(HT)易感性的相关性。方法:选取2014~2015年张家口地区HT患者(病例组)和健康体检者(对照组)各200例,提取外周血DNA后进行PCR测序,检测rs2488457基因型,计算其基因型频率和等位基因频率。结果: rs2488457基因型分布频率与Hardy Weinberg遗传平衡定律一致,各基因型和等位基因分布频率在病例组与对照组差异有统计学意义(P<0.05)。PTPN22 基因-1123G>C位点C/G、C/C基因型可显著提高HT的风险, 携带G/G基因型可能降低HT风险。结论:rs2488457多态性与HT易感性相关。携带C/G、C/C基因型可能是HT发生的危险因素,携带G/G基因型可能是HT发生的保护因素。
英文摘要:
      Objective:To analyze the relationship between the gene polymorphism of -1123G>C loci (rs2488457) and the susceptibility of Hashimoto′s thyroiditis (HT). Methods: 200 cases of HT patients(the case group) and 200 cases of healthy subjects(the control group) were selected from Zhangjiakou area in 2014~2015. DNA was extracted and detected by PCR sequencing. The genotype frequency and allele frequency of rs2488457 gene were calculated. Results: The frequency of rs2488457 genotype was in accordance with Hardy-Weinberg law of genetic equilibrium. There was a significant difference in the frequencies of genotype and allele between the case group and the control group (P<0.05). The C/G and C/C genotype could significantly increase the risk of HT, and the G/G genotype could reduce the risk of HT. Conclusion: rs2488457 polymorphism is associated with susceptibility to HT. Carrying the C/G and C/C genotype was the protective factors of HT.
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