文章摘要
林尧,余伟.参芪扶正注射液联合放化疗治疗高级别脑胶质瘤术后患者的临床观察[J].中国医药导刊,2018,20(2):87-92.
参芪扶正注射液联合放化疗治疗高级别脑胶质瘤术后患者的临床观察
The Clinical Observation of Shenqifuzheng Injection Combined with Postoperative Radiotherapy plus Chemotherapy on Patients with High Grade Glioma
投稿时间:2018-03-16  修订日期:2018-03-28
DOI:
中文关键词: 高级别脑胶质瘤  参芪扶正注射液  放化疗
英文关键词: High grade glioma  Shenqifuzheng injection  Radiotherapy plus chemotherapy
基金项目:
作者单位E-mail
林尧 湖北省黄石爱康医院 25266973@qq.com 
余伟 湖北省宜昌市中心人民医院 18732661@qq.com 
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中文摘要:
      目的: 探讨参芪扶正注射液联合放化疗治疗高级别脑胶质瘤术后患者的治疗效果。方法: 62例患者随机分为两组,对照组32例,术后应用常规放射治疗同步替莫唑胺化疗,及随后的替莫唑胺辅助化疗治疗方案;试验组30例,在对照组治疗方案的基础上,联合应用参芪扶正注射液。治疗前后采用蒙特利尔认知评估量表(MoCA量表)评估两组患者认知功能损害程度,观察两组患者肿瘤体积变化,并对两组患者的放化疗不良反应进行比较。治疗后半年,再次评价两组患者的认知功能。结果: 治疗后两组患者肿瘤缓解率无明显差异,MoCA评分、不良反应发生率试验组均优于对照组,差异有统计学意义(P<0.05)。结论: 在放化疗的基础上,联合应用参芪扶正注射液,能够延缓高级别脑胶质瘤患者术后放疗导致的迟发性认知功能损害,并且能减少放化疗的不良反应。
英文摘要:
      Objective:To explore the therapeutic effect of Shenqifuzheng injection combined with postoperative radiotherapy plus chemotherapy on patients with high grade glioma. Methods: 62 patients were randomly divided into two groups, in the control group, 32 patients were treated with conventional radiotherapy, the concomitant and subsequent adjuvant chemotherapy of timorazolomide were performed; in the test group, 30 patients were treated with Shenqifuzheng injection based on the treatment of the control group. The Montreal cognitive assessment scale (MoCA) was used to assess the degree of cognitive impairment of the two groups, the changes of tumor volume of two groups were observed and the adverse reactions of radiotherapy plus chemotherapy were compared in the two groups before and after therapy. The cognitive function of the two groups was evaluated half a year after treatment again. Results: There was no significant difference in tumor remission rate between the two groups after treatment. The MoCA scores and the incidence of adverse reactions of the test group were better than those of the control group, the differences were statistically significant (P<0.05). Conclusion: On the basis of radiotherapy plus chemotherapy, combined with Shenqifuzheng injection can delay tardive cognitive impairment caused by radiotherapy postoperatively in patients with high grade glioma, and reduce the adverse reactions of radiotherapy plus chemotherapy.
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