文章摘要
丁江涛,赵培培,王富兵.胆汁酸受体TGR5与消化道恶性肿瘤的研究进展[J].中国医药导刊,2019,21(6):338-341.
胆汁酸受体TGR5与消化道恶性肿瘤的研究进展
Research Progress of Bile Acid Receptor TGR5 and Digestive Tract Malignancies
投稿时间:2019-01-26  修订日期:2019-05-26
DOI:
中文关键词: 胆汁酸  TGR5  消化道恶性肿瘤
英文关键词: Bile acid  TGR5  Digestive tract malignancies
基金项目:
作者单位E-mail
丁江涛 南通市第二人民医院 603945718@qq.com 
赵培培 南通市第二人民医院 347890991@qq.com 
王富兵 南通市第二人民医院  
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中文摘要:
      消化道恶性肿瘤是常见的恶性肿瘤之一,目前发病率较高,死亡率亦较高,给全球带来的医疗负担越来越重,因此,寻求预防与治疗的新方法具有重要的意义。TGR5是第一个被证实的G蛋白偶联胆汁酸受体,基因表达分布广泛,包括内分泌腺、脂肪细胞、肌肉、免疫器官、脊髓和肠神经系统,TGR5信号通路可以参与调节葡萄糖代谢和能量代谢、抑制炎性反应和调节细胞增殖等,可能成为预防和治疗消化道肿瘤的新靶点。本文主要讨论了TGR5在代谢、炎性反应和细胞增殖方面的最新进展,并阐述其对消化道肿瘤发生发展的影响以及治疗潜力。
英文摘要:
      Digestive tract malignancies are one of the most common malignant tumors. At present, the incidence rate and the mortality rate of gastrointestinal malignunt tumors are high, which bring more and more medical burden to the world. Therefore, it is of great significance to seek new methods of prevention and treatment. TGR5 is the first confirmed G protein-coupled bile acid receptor with a wide range of gene expression, including endocrine glands, fat cells, muscles, immune organs, spinal cord and enteric nervous system. TGR5 signaling pathway can be involved in the regulation of glucose metabolism and energy metabolism, inhibition of inflammatory reactions and regulation of cell proliferation, which may become the new target for the prevention and treatment of digestive tract tumors. This article mainly discusses the recent advances in TGR5 in metabolism, inflammatory response and cell proliferation, and describes its effects on the development of digestive tract tumors and its therapeutic potential.
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