文章摘要
刘东升,徐继军,苏蕊,姚世霞,朱旭江,杨平荣,贺军权.沉香化滞丸的质量标准提升研究[J].中国医药导刊,2019,21(6):359-364.
沉香化滞丸的质量标准提升研究
Study on Quality Standard Improvement for Chenxiang Huazhi Pills
投稿时间:2019-04-15  修订日期:2019-05-15
DOI:
中文关键词: 沉香化滞丸  薄层色谱法  沉香四醇  高效液相色谱法  质量标准
英文关键词: Chenxiang huazhi pills  TLC  Agarotetrol  HPLC  Quality standard
基金项目:
作者单位E-mail
刘东升 甘肃省药品检验研究院 1067664197@qq.com 
徐继军 甘肃省药品检验研究院  
苏蕊 甘肃省药品检验研究院  
姚世霞 甘肃省药品检验研究院  
朱旭江 甘肃省药品检验研究院  
杨平荣 甘肃省药品检验研究院  
贺军权 甘肃省药品检验研究院  
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中文摘要:
      目的:提升沉香化滞丸的质量标准。方法:对方中厚朴、香附和木香3味药材进行薄层色谱法(TLC)鉴别;使用高效液相色谱法(HPLC)对方中君药沉香中的药效成分沉香四醇进行定量分析。结果:用TLC鉴别厚朴、香附和木香具有较好的专属性;沉香四醇在3.507 3~35.073 4 μg·mL-1浓度范围内与峰面积呈良好的线性关系,相关系数r=0.999 8,平均回收率99.1%,RSD等于1.3%(n=6)。结论:建立的方法操作简单、快速、准确,可用于沉香化滞丸的质量控制。
英文摘要:
      Objective: To improve quality standard for chenxiang huazhi pills. Methods: The TLC method was used for the qualitative identification of Magnoliae Officinalis Cortex, Cyperi Rhizoma, and Radix Aucklandiae, and HPLC method was used to determine agarotetrol, which contained as the major active components of Lignum Aquilariae Resinatum. Results: TLC spots were clear, accurate and repeatable. The linear relationship of agarotetrol was good in the range of 3.507 3-35.073 4 μg·mL-1 (r=0.999 8). The average recovery rate was 99.1%, and RSD was 1.3% (n=6). Conclusion: The established method is simple, rapid, accurate and can be used for quality control of Chenxiang Huazhi pills.
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