文章摘要
朱志远,王海燕,王宏宝,吴波,李微,白旭东,何雪琴,任燕妮,周坛,戴军.急性心肌梗死患者血清hs CRP/PAB、NT-pro BNP、LVEF水平与心力衰竭发生的相关性[J].中国医药导刊,2019,21(7):392-395.
急性心肌梗死患者血清hs CRP/PAB、NT-pro BNP、LVEF水平与心力衰竭发生的相关性
Correlation bwteen Serum hs CRP/PAB, NT-pro BNP, LVEF Levels and Heart Failure in Patients with Acute Myocardial Infarction
投稿时间:2019-05-13  修订日期:2019-08-07
DOI:
中文关键词: 超敏C-反应蛋白与前白蛋白比值  急性心肌梗死  心力衰竭  预测
英文关键词: Hypersensitive C-reactive protein to prealbumin ratio  Acute myocardial infarction  Heart failure  Prediction
基金项目:
作者单位E-mail
朱志远 同济大学附属杨浦医院安图分院心内科 上海200093 zhuzyuan1964@sina.com 
王海燕 同济大学附属杨浦医院安图分部心内科  
王宏宝 同济大学附属杨浦医院安图分部心内科  
吴波 同济大学附属杨浦医院安图分部心内科  
李微 同济大学附属杨浦医院安图分部心内科  
白旭东 同济大学附属杨浦医院安图分部心内科  
何雪琴 同济大学附属杨浦医院安图分部心内科  
任燕妮 同济大学附属杨浦医院安图分部心内科  
周坛 同济大学附属杨浦医院安图分部心内科  
戴军 同济大学附属杨浦医院安图分部心内科  
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中文摘要:
      目的:研究急性心肌梗死(AMI)患者血清超敏C-反应蛋白(hs CRP)与前白蛋白(PAB)比值、N-末端脑钠肽前体(NT-pro BNP)、左心室射血分数(LVEF)水平对其并发心力衰竭(HF)的预测价值。方法:选择2017年1月至2018年6月我院收治的64例AMI患者作为研究对象,测定血糖、血压、血脂、心梗等相关指标。根据Killip心功能分级,将AMI患者分为HF组(n=31)、非HF组(n=33)。比较两组临床指标,分析hs CRP/PAB对AMI患者并发HF的预测价值及诊断效能。结果:与非HF组比较,HF组患者年龄、CKMB、NT-pro BNP、hs CRP、ln(hs CRP/PAB)均升高,LVEF、PAB均降低(P<0.05)。随着Killip心功能分级的增加,AMI并发HF患者血清hs CRP、ln(hs CRP/PAB)均升高,PAB下降(P<0.05)。多因素Logistic回归显示,NT-pro BNP、ln(hs CRP/PAB)是AMI患者并发HF的独立危险因素,而LEVF是保护性因素(P<0.05)。结论:hs CRP/PAB是AMI患者并发HF的独立危险因素,综合血清hs CRP/PAB、NT-pro BNP、LVEF有助于AMI患者并发HF预测评估,从而指导临床决策。
英文摘要:
      Objective: To explore the predictive value of serum hypersensitive C-reactive protein(hs CRP) to prealbumin(PAB) ratio,NT-pro BNP,LVEF levels in patients with acute myocardial infarction(AMI) complicated with heart failure (HF). Methods: Sixty-four patients with AMI admitted from January 2017 to June 2018 in our hospital were selected as the study subjects, and blood glucose, blood pressure, blood lipids, myocardial infarction and other relevant indicators were measured. According to Killip cardiac function grading, AMI patients were divided into HF group (n=31) and non-HF group (n=33). Clinical indicators of the two groups were compared, the predictive value and diagnostic efficacy of hs CRP/PAB for HF in patients with AMI were analyzed. Results: Compared with non-HF group, the age, CKMB, NT-pro BNP, and hs CRP and ln(hs CRP/PAB) were significantly increased in HF group, while LVEF, PAB were significantly decreased (P<0.05). With the increase of Killip cardiac function grading, serum hs CRP and ln(hs CRP/PAB) of AMI patients combined with HF were significantly increased, and PAB was significantly decreased (P<0.05). Multivariate logistic regression showed that NT-pro BNP and ln(hs CRP/PAB) were independent risk factors for HF in AMI patients, while LEVF was a protective factor (P<0.05). Conclusion: Hs CRP/PAB is an independent risk factor for HF in AMI patients. The combination of serum hs CRP/PAB, NT-pro BNP and LVEF can help predict and evaluate HF in AMI patients, and guide the clinical decisions.
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